Effects of neuregulin-1 genetic variation and depression symptom severity on longitudinal patterns of psychotic symptoms in primary care attendees

CA Bousman; M Potiriadis; IP Everall; JM Gunn

Journal article

Effects of neuregulin-1 genetic variation and depression symptom severity on longitudinal patterns of psychotic symptoms in primary care attendees

CA Bousman, M Potiriadis, IP Everall, JM Gunn

American Journal of Medical Genetics Part B Neuropsychiatric Genetics | WILEY-BLACKWELL | Published : 2014

DOI: 10.1002/ajmg.b.32206

Abstract

A better understanding of the factors associated with psychotic symptoms could aid early identification and treatment of psychotic disorders. Previous studies have typically utilized cross-sectional study designs and have focused on individuals with psychotic disorders. Thus, examination of promising correlates of psychotic symptoms using longitudinal designs among more broadly defined populations is warranted. Two such correlates are neuregulin-1 (NRG1) genotypic variation and depression symptom severity. Both NRG1 and depression symptom severity have cross-sectional evidence for an association with psychosis but their affect on longitudinal patterns of psychotic symptoms and their potentia..

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University of Melbourne Researchers

Jane Gunn Author

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Grants

Awarded by National Health and Medical Research Council

Awarded by LEW Carty Chartable Fund

Funding Acknowledgements

Grant sponsor: National Health and Medical Research Council; Grant numbers: 299869, 454463, 566511, 1002908; Grant sponsor: LEW Carty Chartable Fund; Grant number: 7284.